Reaction Cycles of Halogen Species in the Immune Defense: Implications for Human Health and Diseases and the Pathology and Treatment of COVID-19

There is no vaccine or specific antiviral treatment for COVID-19. One current focus is drug repurposing research, but those drugs have limited therapeutic efficacies and known adverse effects. The pathology of COVID-19 is essentially unknown. It is therefore challenging to discover a successful treatment to be approved for clinical use. This paper addresses several key biological processes of reactive oxygen, halogen and nitrogen species (ROS, RHS and RNS) that play crucial physiological roles in organisms from plants to humans. These include why superoxide dismutases, the enzymes to catalyze the formation of H2O2, are required for protecting ROS-induced injury in cell metabolism, why the amount of ROS/RNS produced by ionizing radiation at clinically relevant doses is ~1000 fold lower than the endogenous ROS/RNS level routinely produced in the cell and why a low level of endogenous RHS plays a crucial role in phagocytosis for immune defense. Herein we propose a plausible amplification mechanism in immune defense: ozone-depleting-like halogen cyclic reactions enhancing RHS effects are responsible for all the mentioned physiological functions, which are activated by H2O2 and deactivated by NO signaling molecule. Our results show that the reaction cycles can be repeated thousands of times and amplify the RHS pathogen-killing (defense) effects by 100,000 fold in phagocytosis, resembling the cyclic ozone-depleting reactions in the stratosphere. It is unraveled that H2O2 is a required protective signaling molecule (angel) in the defense system for human health and its dysfunction can cause many diseases or conditions such as autoimmune disorders, aging and cancer. We also identify a class of potent drugs for effective treatment of invading pathogens such as HIV and SARS-CoV-2 (COVID-19), cancer and other diseases, and provide a molecular mechanism of action of the drugs or candidates.Comment: 18 pages, 4 figures, 1 tabl

Theory of magnetoelectric photocurrent generated by direct interband transitions in semiconductor quantum well

A linearly polarized light normally incident on a semiconductor quantum well with spin-orbit coupling may generate pure spin current via direct interband optical transition. An electric photocurrent can be extracted from the pure spin current when an in-plane magnetic field is applied, which has been recently observed in the InGaAs/InAlAs quantum well [Dai et al., Phys. Rev. Lett. 104, 246601 (2010)]. Here we present a theoretical study of this magnetoelectric photocurrent effect associated with the interband transition. By employing the density matrix formalism, we show that the photoexcited carrier density has an anisotropic distribution in k space, strongly dependent on the orientation of the electron wavevector and the polarization of the light. This anisotropy provides an intuitive picture of the observed dependence of the photocurrent on the magnetic field and the polarization of the light. We also show that the ratio of the pure spin photocurrent to the magnetoelectric photocurrent is approximately equal to the ratio of the kinetic energy to the Zeeman energy, which enables us to estimate the magnitude of the pure spin photocurrent. The photocurrent density calculated with the help of an anisotropic Rashba model and the Kohn-Luttinger model can produce all three terms in the fitting formula for measured current, with comparable order of magnitude, but discrepancies are still present and further investigation is needed.Comment: 13 pages, 9 figures, 2 table

Spin-bias driven magnetization reversal and nondestructive detection in a single molecular magnet

The magnetization reversal in a single molecular magnet (SMM) weakly coupled to an electrode with spin-dependent splitting of chemical potentials (spin bias) is theoretically investigated by means of the rate equation. A microscopic mechanism for the reversal is demonstrated by the avalanche dynamics at the reversal point. The magnetization as a function of the spin bias shows hysteresis loops tunable by the gate voltage and varying with temperature. The nondestructive measurement to the orientation of giant spin in SMM is presented by measuring the fully polarized electric current in the response to a small spin bias. For Mn$_{12}$ac molecule, its small transverse anisotropy only slightly violates the results above. The situation when there is an angle between the easy axis of the SMM and the spin quantization direction of the electrode is also studied.Comment: 17 pages, 12 figure

Determining coupling dynamic stiffness of structural connection by tested FRFs

Identifying coupling dynamic stiffness of structural connection is often needed in substructural dynamic analysis. To overcome the faultiness of conventional approaches existed, five indirect schemes of inverse substructuring analysis by using tested frequency response functions (FRFs) are provided. And the first indirect scheme is verified by three mass-rubber models constructed as two-level substructures with mono-coupling, bi-coupling and tri-coupling connection. Compared to existing direct scheme of inverse substructuring analysis, it shows better performance with acceptable precision of determining the stiffness

Experimental verification on applying indirect inverse substructuring analysis to identify coupling dynamic stiffness of mechanical assembly via planar surface

To broaden the engineering application of inverse substructuring analysis, the mechanical assembly via planar surface is experimentally studied. Specifically, the first and the second schemes of indirect inverse substructuring analysis are applied to identify the coupling dynamic stiffness of the assembly. The experimental model of the assembly is designed, and the surface is then discretized equivalently into point-to-point connections for testing the frequency response functions (FRFs) involved in the schemes. Experimental results show that, applying both of the schemes are feasible for the identification, and the identified stiffnesses approach to be stable as the number of discretized points increases

Coupling dynamic stiffness identification of mechanical assembly with linear connection by the second indirect scheme of inverse substructuring analysis

A non-ideal connection of mechanical assembly with linear assembling interface is firstly considered in the coupling dynamic stiffness identification by applying the second scheme of indirect inverse substructuring analysis. The experimental model of the mechanical assembly is designed, and the interface is then discretized equivalently as ideal point-coupling for testing the frequency response functions (FRFs) involved in the scheme. As the results of the experimental study, applying the scheme is verified to be feasible for the stiffness identification of a mechanical assembly with linear connection, and the identified stiffness approaches to be stable with increase of the number of discretized points